5am Venture Management, LLC

Investment Portfolio & 13F Holdings Analysis

About

Type: FundHoldings: 31Value: $264.4MLatest: 2025Q1

5AM Venture Management, LLC is an institutional investment manager that filed its latest Form 13F for 2025Q1, reporting 31 holdings worth $0.3 billion. Form 13F filings provide transparency into the equity holdings of institutional investment managers with over $100 million in assets under management. This page displays the most recent portfolio holdings, allowing investors to track position changes, new investments, and portfolio composition.

AI_NATIVE detailed information: This accession holds the following tickers:[
  "CNTA",
  "SKYE",
  "ANAB",
  "SLN",
  "TYRA",
  "TECX",
  "PHVS",
  "ADVM",
  "ALEC",
  "ARTV",
  "CAMP",
  "MRSN",
  "RLYB",
  "SRZN",
  "GHRS",
  "TARA",
  "PRAX",
  "MLTX",
  "SCPH",
  "CDTX",
  "ERAS",
  "ELVN",
  "EYPT",
  "VKTX",
  "VRDN",
  "VOR",
  "ZNTL",
  "TRDA",
  "BHVN",
  "CLDX",
  "DNTH"
]

Filing Details

13F-HR • 2025-03-31

SEC FilingSEC DataHachi Filing

Report Date: 2025-03-31
Filing Date: 2025-05-15
Total Holdings: 31
Total Value: 264407625
Accession Number: 0001085146-25-003293
Form Type: 13F-HR
CIK: 5am-venture-management
Manager Name: 5am-Venture-Management

Data Enrichment

100% identified

31 identified0 unidentified

Holdings

SEC FilingSEC DataHachi Filing

Manager:

31 positions • $264.4M total value

SEC FilingSEC DataHachi Filing

Manager:

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Entrada Therapeutics, Inc.

TRDA|29384C108

Shares:4.4M

Value:$39.9M

% of Portfolio:15.1% ($39.9M/$264.4M)

Enliven Therapeutics, Inc.

ELVN|29337E102

Shares:1.3M

Value:$26.0M

% of Portfolio:9.8% ($26.0M/$264.4M)

Dianthus Therapeutics, Inc. /DE/

DNTH|252828108

Shares:1.0M

Value:$18.6M

% of Portfolio:7.1% ($18.6M/$264.4M)

Skye Bioscience, Inc.

SKYE|83086J200

Shares:9.9M

Value:$15.8M

% of Portfolio:6.0% ($15.8M/$264.4M)

Pharvaris N.V.

PHVS|N69605108

Shares:797.6K

Value:$12.5M

% of Portfolio:4.7% ($12.5M/$264.4M)

Centessa Pharmaceuticals plc

CNTA|152309100

Shares:830.9K

Value:$11.9M

% of Portfolio:4.5% ($11.9M/$264.4M)

Camp4 Therapeutics Corp

CAMP|13463J101

Shares:2.9M

Value:$11.7M

% of Portfolio:4.4% ($11.7M/$264.4M)

Biohaven Ltd.

BHVN|G1110E107

Shares:479.0K

Value:$11.5M

% of Portfolio:4.4% ($11.5M/$264.4M)

MoonLake Immunotherapeutics

MLTX|61559X104

Shares:282.3K

Value:$11.0M

% of Portfolio:4.2% ($11.0M/$264.4M)

Viridian Therapeutics, Inc.\DE

VRDN|92790C104

Shares:736.6K

Value:$9.9M

% of Portfolio:3.8% ($9.9M/$264.4M)

Tectonic Therapeutic, Inc.

TECX|878972108

Shares:511.7K

Value:$9.1M

% of Portfolio:3.4% ($9.1M/$264.4M)

Celldex Therapeutics, Inc.

CLDX|15117B202

Shares:497.3K

Value:$9.0M

% of Portfolio:3.4% ($9.0M/$264.4M)

Tyra Biosciences, Inc.

TYRA|90240B106

Shares:939.3K

Value:$8.7M

% of Portfolio:3.3% ($8.7M/$264.4M)

Erasca, Inc.

ERAS|29479A108

Shares:5.4M

Value:$7.4M

% of Portfolio:2.8% ($7.4M/$264.4M)

Artiva Biotherapeutics, Inc.

ARTV|04317A107

Shares:2.4M

Value:$7.1M

% of Portfolio:2.7% ($7.1M/$264.4M)

ANAPTYSBIO, INC

ANAB|032724106

Shares:357.7K

Value:$6.7M

% of Portfolio:2.5% ($6.7M/$264.4M)

Praxis Precision Medicines, Inc.

PRAX|74006W207

Shares:170.0K

Value:$6.4M

% of Portfolio:2.4% ($6.4M/$264.4M)

GH Research PLC

GHRS|G3855L106

Shares:572.7K

Value:$6.3M

% of Portfolio:2.4% ($6.3M/$264.4M)

EyePoint Pharmaceuticals, Inc.

EYPT|30233G209

Shares:1.1M

Value:$5.7M

% of Portfolio:2.2% ($5.7M/$264.4M)

Viking Therapeutics, Inc.

VKTX|92686J106

Shares:189.6K

Value:$4.6M

% of Portfolio:1.7% ($4.6M/$264.4M)

Instrument	Shares		Other Manager	Value	% of Portfolio
Entrada Therapeutics, Inc.(TRDAcusip29384C108)	4.4M	QoQ 0.00% (-0) YoY 0.00% (-0)	All Managers (Combined)	$39.9M	15.1% ($39.9M/$264.4M)	QoQ -47.71% (-$36.4M) YoY -36.20% (-$22.6M)
Enliven Therapeutics, Inc.(ELVNcusip29337E102)	1.3M	QoQ -18.85% (-307.3K) YoY -65.52% (-2.5M)	All Managers (Combined)	$26.0M	9.8% ($26.0M/$264.4M)	QoQ -29.02% (-$10.6M) YoY -61.42% (-$41.4M)
Dianthus Therapeutics, Inc. /DE/(DNTHcusip252828108)	1.0M	QoQ 0.00% (-0) YoY -17.25% (-214.3K)	All Managers (Combined)	$18.6M	7.1% ($18.6M/$264.4M)	QoQ -16.78% (-$3.8M) YoY -49.96% (-$18.6M)
Skye Bioscience, Inc.(SKYEcusip83086J200)	9.9M	QoQ 0.00% (-0) YoY NEW(+9.9M)	All Managers (Combined)	$15.8M	6.0% ($15.8M/$264.4M)	QoQ -43.81% (-$12.3M) YoY NEW(+$15.8M)
Pharvaris N.V.(PHVScusipN69605108)	797.6K	QoQ 0.00% (-0) YoY 0.00% (-0)	All Managers (Combined)	$12.5M	4.7% ($12.5M/$264.4M)	QoQ -18.10% (-$2.8M) YoY -32.06% (-$5.9M)
Centessa Pharmaceuticals plc(CNTAcusip152309100)	830.9K	QoQ 0.00% (-0) YoY -33.25% (-414.1K)	All Managers (Combined)	$11.9M	4.5% ($11.9M/$264.4M)	QoQ -14.14% (-$2.0M) YoY -15.06% (-$2.1M)
Camp4 Therapeutics Corp(CAMPcusip13463J101)	2.9M	QoQ 0.00% (-0) YoY NEW(+2.9M)	All Managers (Combined)	$11.7M	4.4% ($11.7M/$264.4M)	QoQ -23.37% (-$3.6M) YoY NEW(+$11.7M)
Biohaven Ltd.(BHVNcusipG1110E107)	479.0K	QoQ 0.00% (-0) YoY +49.69% (-159.0K)	All Managers (Combined)	$11.5M	4.4% ($11.5M/$264.4M)	QoQ -35.63% (-$6.4M) YoY -34.20% (-$6.0M)
MoonLake Immunotherapeutics(MLTXcusip61559X104)	282.3K	QoQ 0.00% (-0) YoY 0.00% (-0)	All Managers (Combined)	$11.0M	4.2% ($11.0M/$264.4M)	QoQ -27.84% (-$4.3M) YoY -22.21% (-$3.2M)
Viridian Therapeutics, Inc.\DE(VRDNcusip92790C104)	736.6K	QoQ 0.00% (-0) YoY 0.00% (-0)	All Managers (Combined)	$9.9M	3.8% ($9.9M/$264.4M)	QoQ -29.68% (-$4.2M) YoY -23.01% (-$3.0M)
Tectonic Therapeutic, Inc.(TECXcusip878972108)	511.7K	QoQ -14.24% (-85.0K) YoY NEW(+511.7K)	All Managers (Combined)	$9.1M	3.4% ($9.1M/$264.4M)	QoQ -67.10% (-$18.5M) YoY NEW(+$9.1M)
Celldex Therapeutics, Inc.(CLDXcusip15117B202)	497.3K	QoQ 0.00% (-0) YoY 0.00% (-0)	All Managers (Combined)	$9.0M	3.4% ($9.0M/$264.4M)	QoQ -28.17% (-$3.5M) YoY -56.75% (-$11.8M)
Tyra Biosciences, Inc.(TYRAcusip90240B106)	939.3K	QoQ 0.00% (-0) YoY 0.00% (-0)	All Managers (Combined)	$8.7M	3.3% ($8.7M/$264.4M)	QoQ -33.09% (-$4.3M) YoY -43.29% (-$6.7M)
Erasca, Inc.(ERAScusip29479A108)	5.4M	QoQ 0.00% (-0) YoY NEW(+5.4M)	All Managers (Combined)	$7.4M	2.8% ($7.4M/$264.4M)	QoQ -45.41% (-$6.2M) YoY NEW(+$7.4M)
Artiva Biotherapeutics, Inc.(ARTVcusip04317A107)	2.4M	QoQ 0.00% (-0) YoY NEW(+2.4M)	All Managers (Combined)	$7.1M	2.7% ($7.1M/$264.4M)	QoQ -70.23% (-$16.7M) YoY NEW(+$7.1M)
ANAPTYSBIO, INC(ANABcusip032724106)	357.7K	QoQ 0.00% (+0) YoY 0.00% (-0)	All Managers (Combined)	$6.7M	2.5% ($6.7M/$264.4M)	QoQ +40.40% (+$1.9M) YoY -17.45% (-$1.4M)
Praxis Precision Medicines, Inc.(PRAXcusip74006W207)	170.0K	QoQ 0.00% (-0) YoY -50.00% (-170.0K)	All Managers (Combined)	$6.4M	2.4% ($6.4M/$264.4M)	QoQ -50.79% (-$6.6M) YoY -68.96% (-$14.3M)
GH Research PLC(GHRScusipG3855L106)	572.7K	QoQ 0.00% (+0) YoY 0.00% (+0)	All Managers (Combined)	$6.3M	2.4% ($6.3M/$264.4M)	QoQ +57.57% (+$2.3M) YoY +3.47% (+$211.9K)
EyePoint Pharmaceuticals, Inc.(EYPTcusip30233G209)	1.1M	QoQ 0.00% (-0) YoY NEW(+1.1M)	All Managers (Combined)	$5.7M	2.2% ($5.7M/$264.4M)	QoQ -27.24% (-$2.1M) YoY NEW(+$5.7M)
Viking Therapeutics, Inc.(VKTXcusip92686J106)	189.6K	QoQ 0.00% (-0) YoY -20.19% (-48.0K)	All Managers (Combined)	$4.6M	1.7% ($4.6M/$264.4M)	QoQ -39.98% (-$3.1M) YoY -76.49% (-$14.9M)