Casdin Capital, LLC

Investment Portfolio & 13F Holdings Analysis

About

Type: FundHoldings: 44Value: $1.2BLatest: 2025Q1

Casdin Capital, LLC is an institutional investment manager that filed its latest Form 13F for 2025Q1, reporting 44 holdings worth $1.2 billion. Form 13F filings provide transparency into the equity holdings of institutional investment managers with over $100 million in assets under management. This page displays the most recent portfolio holdings, allowing investors to track position changes, new investments, and portfolio composition.

AI_NATIVE detailed information: This accession holds the following tickers:[
  "ABSI",
  "RVMD",
  "WGS",
  "EXAS",
  "ALNY",
  "VCYT",
  "DNA",
  "PRME",
  "RXRX",
  "TNGX",
  "GPCR",
  "RLAY",
  "SNDX",
  "GLUE",
  "NGNE",
  "TSVT",
  "CTNM",
  "GH",
  null,
  "SEPN",
  "LAB",
  "TNYA",
  "ILMN",
  "GEHC",
  "RNA",
  "AGIO",
  "MRNA",
  "SLDB",
  "NTLA",
  "DYN",
  "SRPT",
  "KRON",
  "HIMS",
  "VERV",
  "VSTM",
  "TDOC",
  "PACB",
  "BEAM",
  null,
  "BLFS",
  "BPMC",
  "IPSC",
  "CDXS",
  "DNLI"
]

Filing Details

13F-HR • 2025-03-31

SEC FilingSEC DataHachi Filing

Report Date: 2025-03-31
Filing Date: 2025-05-15
Total Holdings: 44
Total Value: 1223806401
Accession Number: 0000919574-25-003248
Form Type: 13F-HR
CIK: casdin-capital
Manager Name: Casdin-Capital

Data Enrichment

95% identified

42 identified2 unidentified

Holdings

SEC FilingSEC DataHachi Filing

Manager:

44 positions • $1.2B total value

SEC FilingSEC DataHachi Filing

Manager:

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GeneDx Holdings Corp.

WGS|81663L200

Shares:3.5M

Value:$310.6M

% of Portfolio:25.4% ($310.6M/$1.2B)

BIOLIFE SOLUTIONS INC

BLFS|09062W204

Shares:8.7M

Value:$198.9M

% of Portfolio:16.3% ($198.9M/$1.2B)

Revolution Medicines, Inc.

RVMD|76155X100

Shares:3.7M

Value:$130.8M

% of Portfolio:10.7% ($130.8M/$1.2B)

STANDARD BIOTOOLS INC.

LAB|34385P108

Shares:76.1M

Value:$82.2M

% of Portfolio:6.7% ($82.2M/$1.2B)

Avidity Biosciences, Inc.

RNA|05370A108

Shares:2.0M

Value:$60.4M

% of Portfolio:4.9% ($60.4M/$1.2B)

Sarepta Therapeutics, Inc.

SRPT|803607100

Shares:900.8K

Value:$57.5M

% of Portfolio:4.7% ($57.5M/$1.2B)

ILLUMINA, INC.

ILMN|452327109

Shares:595.0K

Value:$47.2M

% of Portfolio:3.9% ($47.2M/$1.2B)

ALNYLAM PHARMACEUTICALS, INC.

ALNY|02043Q107

Shares:120.0K

Value:$32.4M

% of Portfolio:2.6% ($32.4M/$1.2B)

Blueprint Medicines Corp

BPMC|09627Y109

Shares:326.4K

Value:$28.9M

% of Portfolio:2.4% ($28.9M/$1.2B)

Beam Therapeutics Inc.

BEAM|07373V105

Shares:1.4M

Value:$27.8M

% of Portfolio:2.3% ($27.8M/$1.2B)

Relay Therapeutics, Inc.

RLAY|75943R102

Shares:9.1M

Value:$23.8M

% of Portfolio:1.9% ($23.8M/$1.2B)

CODEXIS, INC.

CDXS|192005106

Shares:8.1M

Value:$21.8M

% of Portfolio:1.8% ($21.8M/$1.2B)

Verve Therapeutics, Inc.

VERV|92539P101

Shares:4.0M

Value:$18.3M

% of Portfolio:1.5% ($18.3M/$1.2B)

EXACT SCIENCES CORP

EXAS|30063P105

Shares:405.0K

Value:$17.5M

% of Portfolio:1.4% ($17.5M/$1.2B)

Neurogene Inc.

NGNE|64135M105

Shares:1.3M

Value:$15.2M

% of Portfolio:1.2% ($15.2M/$1.2B)

Intellia Therapeutics, Inc.

NTLA|45826J105

Shares:2.0M

Value:$14.2M

% of Portfolio:1.2% ($14.2M/$1.2B)

Denali Therapeutics Inc.

DNLI|24823R105

Shares:990.0K

Value:$13.5M

% of Portfolio:1.1% ($13.5M/$1.2B)

Structure Therapeutics Inc.

GPCR|86366E106

Shares:700.0K

Value:$12.1M

% of Portfolio:1.0% ($12.1M/$1.2B)

07725L102

Shares:40.0K

Value:$10.9M

% of Portfolio:0.9% ($10.9M/$1.2B)

Guardant Health, Inc.

GH|40131M109

Shares:250.0K

Value:$10.7M

% of Portfolio:0.9% ($10.7M/$1.2B)

Instrument	Shares		Other Manager	Value	% of Portfolio
GeneDx Holdings Corp.(WGScusip81663L200)	3.5M	QoQ 0.00% (+0) YoY +11.82% (+370.8K)	All Managers (Combined)	$310.6M	25.4% ($310.6M/$1.2B)	QoQ +15.22% (+$41.1M) YoY +984.71% (+$282.0M)
BIOLIFE SOLUTIONS INC(BLFScusip09062W204)	8.7M	QoQ 0.00% (-0) YoY 0.00% (+0)	All Managers (Combined)	$198.9M	16.3% ($198.9M/$1.2B)	QoQ -12.01% (-$27.2M) YoY +23.12% (+$37.4M)
Revolution Medicines, Inc.(RVMDcusip76155X100)	3.7M	QoQ -0.03% (-1.4K) YoY -34.17% (-1.9M)	All Managers (Combined)	$130.8M	10.7% ($130.8M/$1.2B)	QoQ -19.18% (-$31.0M) YoY -27.77% (-$50.3M)
STANDARD BIOTOOLS INC.(LABcusip34385P108)	76.1M	QoQ +6.76% (-4.8M) YoY +22.88% (-14.2M)	All Managers (Combined)	$82.2M	6.7% ($82.2M/$1.2B)	QoQ -34.11% (-$42.5M) YoY -51.02% (-$85.6M)
Avidity Biosciences, Inc.(RNAcusip05370A108)	2.0M	QoQ 0.00% (+0) YoY -1.91% (-39.8K)	All Managers (Combined)	$60.4M	4.9% ($60.4M/$1.2B)	QoQ +1.51% (+$899.8K) YoY +13.46% (-$7.2M)
Sarepta Therapeutics, Inc.(SRPTcusip803607100)	900.8K	QoQ -16.08% (-172.7K) YoY -15.73% (-168.2K)	All Managers (Combined)	$57.5M	4.7% ($57.5M/$1.2B)	QoQ -55.95% (-$73.0M) YoY -58.46% (-$80.9M)
ILLUMINA, INC.(ILMNcusip452327109)	595.0K	QoQ -20.66% (-155.0K) YoY +139.91% (+347.0K)	All Managers (Combined)	$47.2M	3.9% ($47.2M/$1.2B)	QoQ -52.89% (-$53.0M) YoY +38.61% (+$13.2M)
ALNYLAM PHARMACEUTICALS, INC.(ALNYcusip02043Q107)	120.0K	QoQ -14.28% (-20.0K) YoY -66.48% (-238.0K)	All Managers (Combined)	$32.4M	2.6% ($32.4M/$1.2B)	QoQ -1.64% (-$541.0K) YoY -39.43% (-$21.1M)
Blueprint Medicines Corp(BPMCcusip09627Y109)	326.4K	QoQ 0.00% (+0) YoY 0.00% (-0)	All Managers (Combined)	$28.9M	2.4% ($28.9M/$1.2B)	QoQ +1.47% (+$421.0K) YoY -6.69% (-$2.1M)
Beam Therapeutics Inc.(BEAMcusip07373V105)	1.4M	QoQ +14.04% (-175.6K) YoY +111.19% (+750.6K)	All Managers (Combined)	$27.8M	2.3% ($27.8M/$1.2B)	QoQ -10.18% (-$3.2M) YoY +24.83% (+$5.5M)
Relay Therapeutics, Inc.(RLAYcusip75943R102)	9.1M	QoQ +1.67% (-150.0K) YoY +22.56% (-1.7M)	All Managers (Combined)	$23.8M	1.9% ($23.8M/$1.2B)	QoQ -35.34% (-$13.0M) YoY -61.31% (-$37.8M)
CODEXIS, INC.(CDXScusip192005106)	8.1M	QoQ 0.00% (-0) YoY +305.00% (+6.1M)	All Managers (Combined)	$21.8M	1.8% ($21.8M/$1.2B)	QoQ -43.60% (-$16.8M) YoY +212.16% (+$14.8M)
Verve Therapeutics, Inc.(VERVcusip92539P101)	4.0M	QoQ 0.00% (-0) YoY +30.61% (-936.5K)	All Managers (Combined)	$18.3M	1.5% ($18.3M/$1.2B)	QoQ -18.97% (-$4.3M) YoY -55.05% (-$22.4M)
EXACT SCIENCES CORP(EXAScusip30063P105)	405.0K	QoQ -37.69% (-245.0K) YoY -37.69% (-245.0K)	All Managers (Combined)	$17.5M	1.4% ($17.5M/$1.2B)	QoQ -51.99% (-$19.0M) YoY -60.94% (-$27.4M)
Neurogene Inc.(NGNEcusip64135M105)	1.3M	QoQ 0.00% (-0) YoY +146.91% (-770.7K)	All Managers (Combined)	$15.2M	1.2% ($15.2M/$1.2B)	QoQ -48.77% (-$14.4M) YoY -43.19% (-$11.5M)
Intellia Therapeutics, Inc.(NTLAcusip45826J105)	2.0M	QoQ 0.00% (-0) YoY +3900.00% (+1.9M)	All Managers (Combined)	$14.2M	1.2% ($14.2M/$1.2B)	QoQ -39.02% (-$9.1M) YoY +933.80% (+$12.8M)
Denali Therapeutics Inc.(DNLIcusip24823R105)	990.0K	QoQ 0.00% (-0) YoY -23.84% (-310.0K)	All Managers (Combined)	$13.5M	1.1% ($13.5M/$1.2B)	QoQ -33.29% (-$6.7M) YoY -49.54% (-$13.2M)
Structure Therapeutics Inc.(GPCRcusip86366E106)	700.0K	QoQ 0.00% (-0) YoY -37.32% (-416.9K)	All Managers (Combined)	$12.1M	1.0% ($12.1M/$1.2B)	QoQ -36.17% (-$6.9M) YoY -74.68% (-$35.8M)
(cusip07725L102)✕	40.0K	QoQ NEW(+40.0K) YoY NEW(+40.0K)	All Managers (Combined)	$10.9M	0.9% ($10.9M/$1.2B)	QoQ NEW(+$10.9M) YoY NEW(+$10.9M)
Guardant Health, Inc.(GHcusip40131M109)	250.0K	QoQ -28.57% (-100.0K) YoY NEW(+250.0K)	All Managers (Combined)	$10.7M	0.9% ($10.7M/$1.2B)	QoQ -0.39% (-$42.5K) YoY NEW(+$10.7M)