Opaleye Management Inc.

Investment Portfolio & 13F Holdings Analysis

About

Type: FundHoldings: 45Value: $449.2MLatest: 2025Q1

Opaleye Management Inc. is an institutional investment manager that filed its latest Form 13F for 2025Q1, reporting 45 holdings worth $0.4 billion. Form 13F filings provide transparency into the equity holdings of institutional investment managers with over $100 million in assets under management. This page displays the most recent portfolio holdings, allowing investors to track position changes, new investments, and portfolio composition.

AI_NATIVE detailed information: This accession holds the following tickers:[
  "OCUL",
  "KNSA",
  "EWTX",
  "TRVI",
  "TGTX",
  "DNA",
  "SGMO",
  "ARVN",
  "ANAB",
  "SLRN",
  "LQDA",
  "NRIX",
  "STOK",
  "LRMR",
  "ADGM",
  "ANIK",
  "EPIX",
  null,
  null,
  "PVLA",
  null,
  "BDSX",
  "TARA",
  "RZLT",
  "ZYME",
  null,
  "PTGX",
  "PEPG",
  "MBX",
  "RYTM",
  "IBIO",
  "RCEL",
  "GOSS",
  "HROW",
  "IMNM",
  "DERM",
  "ETON",
  "VTYX",
  "XOMA",
  "ZNTL",
  "OPTN",
  "CRGX",
  "CGON",
  "CDXS",
  "IRON"
]

Filing Details

13F-HR • 2025-03-31

SEC FilingSEC DataHachi Filing

Report Date: 2025-03-31
Filing Date: 2025-05-15
Total Holdings: 45
Total Value: 449152370
Accession Number: 0001641172-25-010914
Form Type: 13F-HR
CIK: opaleye-management
Manager Name: Opaleye-Management

Data Enrichment

91% identified

41 identified4 unidentified

Holdings

SEC FilingSEC DataHachi Filing

Manager:

45 positions • $449.2M total value

SEC FilingSEC DataHachi Filing

Manager:

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HARROW, INC.

HROW|415858109

Shares:4.0M

Value:$105.2M

% of Portfolio:23.4% ($105.2M/$449.2M)

Eton Pharmaceuticals, Inc.

ETON|29772L108

Shares:2.9M

Value:$37.0M

% of Portfolio:8.2% ($37.0M/$449.2M)

80303D305

Shares:972.0K

Value:$34.4M

% of Portfolio:7.7% ($34.4M/$449.2M)

Liquidia Corp

LQDA|53635D202

Shares:2.3M

Value:$33.3M

% of Portfolio:7.4% ($33.3M/$449.2M)

RHYTHM PHARMACEUTICALS, INC.

RYTM|76243J105

Shares:490.0K

Value:$26.0M

% of Portfolio:5.8% ($26.0M/$449.2M)

CODEXIS, INC.

CDXS|192005106

Shares:9.5M

Value:$25.6M

% of Portfolio:5.7% ($25.6M/$449.2M)

Immunome Inc.

IMNM|45257U108

Shares:3.5M

Value:$23.9M

% of Portfolio:5.3% ($23.9M/$449.2M)

TG THERAPEUTICS, INC.

TGTX|88322Q108

Shares:535.0K

Value:$21.1M

% of Portfolio:4.7% ($21.1M/$449.2M)

ARVINAS, INC.

ARVN|04335A105

Shares:2.0M

Value:$13.9M

% of Portfolio:3.1% ($13.9M/$449.2M)

OCULAR THERAPEUTIX, INC

OCUL|67576A100

Shares:1.6M

Value:$11.7M

% of Portfolio:2.6% ($11.7M/$449.2M)

Edgewise Therapeutics, Inc.

EWTX|28036F105

Shares:395.0K

Value:$8.7M

% of Portfolio:1.9% ($8.7M/$449.2M)

Protara Therapeutics, Inc.

TARA|74365U107

Shares:1.7M

Value:$7.4M

% of Portfolio:1.6% ($7.4M/$449.2M)

Ginkgo Bioworks Holdings, Inc.

DNA|37611X209

Shares:1.2M

Value:$6.8M

% of Portfolio:1.5% ($6.8M/$449.2M)

38341PAA0

Shares:—

Value:$6.3M

% of Portfolio:1.4% ($6.3M/$449.2M)

Anika Therapeutics, Inc.

ANIK|035255108

Shares:395.0K

Value:$5.9M

% of Portfolio:1.3% ($5.9M/$449.2M)

Protagonist Therapeutics, Inc

PTGX|74366E102

Shares:105.0K

Value:$5.1M

% of Portfolio:1.1% ($5.1M/$449.2M)

XOMA Royalty Corp

XOMA|98419J206

Shares:253.0K

Value:$5.0M

% of Portfolio:1.1% ($5.0M/$449.2M)

Trevi Therapeutics, Inc.

TRVI|89532M101

Shares:795.0K

Value:$5.0M

% of Portfolio:1.1% ($5.0M/$449.2M)

PALVELLA THERAPEUTICS, INC.

PVLA|697947109

Shares:172.4K

Value:$4.8M

% of Portfolio:1.1% ($4.8M/$449.2M)

Gossamer Bio, Inc.

GOSS|38341P102

Shares:4.3M

Value:$4.7M

% of Portfolio:1.1% ($4.7M/$449.2M)

Instrument	Shares		Other Manager	Value	% of Portfolio
HARROW, INC.(HROWcusip415858109)	4.0M	QoQ -0.87% (-35.0K) YoY +0.87% (+34.4K)	All Managers (Combined)	$105.2M	23.4% ($105.2M/$449.2M)	QoQ -21.41% (-$28.7M) YoY +102.82% (+$53.3M)
Eton Pharmaceuticals, Inc.(ETONcusip29772L108)	2.9M	QoQ 0.00% (-0) YoY +16.61% (+406.3K)	All Managers (Combined)	$37.0M	8.2% ($37.0M/$449.2M)	QoQ -2.55% (-$969.7K) YoY +303.63% (+$27.8M)
(cusip80303D305)✕	972.0K	QoQ NEW(+972.0K) YoY NEW(+972.0K)	All Managers (Combined)	$34.4M	7.7% ($34.4M/$449.2M)	QoQ NEW(+$34.4M) YoY NEW(+$34.4M)
Liquidia Corp(LQDAcusip53635D202)	2.3M	QoQ +33.08% (+561.9K) YoY +472.15% (+1.9M)	All Managers (Combined)	$33.3M	7.4% ($33.3M/$449.2M)	QoQ +66.92% (+$13.4M) YoY +472.15% (+$27.5M)
RHYTHM PHARMACEUTICALS, INC.(RYTMcusip76243J105)	490.0K	QoQ -2.00% (-10.0K) YoY -4.85% (-25.0K)	All Managers (Combined)	$26.0M	5.8% ($26.0M/$449.2M)	QoQ -7.26% (-$2.0M) YoY +16.31% (-$3.6M)
CODEXIS, INC.(CDXScusip192005106)	9.5M	QoQ +7.46% (-660.0K) YoY +204.48% (+6.4M)	All Managers (Combined)	$25.6M	5.7% ($25.6M/$449.2M)	QoQ -39.39% (-$16.6M) YoY +134.69% (+$14.7M)
Immunome Inc.(IMNMcusip45257U108)	3.5M	QoQ +74.01% (+1.5M) YoY NEW(+3.5M)	All Managers (Combined)	$23.9M	5.3% ($23.9M/$449.2M)	QoQ +10.27% (+$2.2M) YoY NEW(+$23.9M)
TG THERAPEUTICS, INC.(TGTXcusip88322Q108)	535.0K	QoQ -76.32% (-1.7M) YoY -76.53% (-1.7M)	All Managers (Combined)	$21.1M	4.7% ($21.1M/$449.2M)	QoQ -68.98% (-$46.9M) YoY -39.17% (-$13.6M)
ARVINAS, INC.(ARVNcusip04335A105)	2.0M	QoQ +21.53% (-350.0K) YoY +498.48% (+1.6M)	All Managers (Combined)	$13.9M	3.1% ($13.9M/$449.2M)	QoQ -58.78% (-$19.8M) YoY +1.77% (+$242.1K)
OCULAR THERAPEUTIX, INC(OCULcusip67576A100)	1.6M	QoQ -63.27% (-2.7M) YoY -76.02% (-5.1M)	All Managers (Combined)	$11.7M	2.6% ($11.7M/$449.2M)	QoQ -68.47% (-$25.4M) YoY -80.68% (-$48.9M)
Edgewise Therapeutics, Inc.(EWTXcusip28036F105)	395.0K	QoQ -17.70% (-85.0K) YoY -40.60% (-270.0K)	All Managers (Combined)	$8.7M	1.9% ($8.7M/$449.2M)	QoQ -32.19% (-$4.1M) YoY -28.35% (-$3.4M)
Protara Therapeutics, Inc.(TARAcusip74365U107)	1.7M	QoQ -5.20% (-95.0K) YoY -35.74% (-962.6K)	All Managers (Combined)	$7.4M	1.6% ($7.4M/$449.2M)	QoQ -23.51% (-$2.3M) YoY -31.74% (-$3.4M)
Ginkgo Bioworks Holdings, Inc.(DNAcusip37611X209)	1.2M	QoQ -0.41% (-5.0K) YoY NEW(+1.2M)	All Managers (Combined)	$6.8M	1.5% ($6.8M/$449.2M)	QoQ -42.19% (-$5.0M) YoY NEW(+$6.8M)
(cusip38341PAA0)✕	—	QoQ - YoY -	All Managers (Combined)	$6.3M	1.4% ($6.3M/$449.2M)	QoQ +3.75% (+$228.9K) YoY +96.68% (+$3.1M)
Anika Therapeutics, Inc.(ANIKcusip035255108)	395.0K	QoQ NEW(+395.0K) YoY NEW(+395.0K)	All Managers (Combined)	$5.9M	1.3% ($5.9M/$449.2M)	QoQ NEW(+$5.9M) YoY NEW(+$5.9M)
Protagonist Therapeutics, Inc(PTGXcusip74366E102)	105.0K	QoQ 0.00% (+0) YoY -6.83% (-7.7K)	All Managers (Combined)	$5.1M	1.1% ($5.1M/$449.2M)	QoQ +25.28% (+$1.0M) YoY +55.74% (-$1.8M)
XOMA Royalty Corp(XOMAcusip98419J206)	253.0K	QoQ +1.21% (-3.0K) YoY +1.21% (-3.0K)	All Managers (Combined)	$5.0M	1.1% ($5.0M/$449.2M)	QoQ -23.23% (-$1.5M) YoY -16.12% (-$969.4K)
Trevi Therapeutics, Inc.(TRVIcusip89532M101)	795.0K	QoQ -65.69% (-1.5M) YoY -69.94% (-1.9M)	All Managers (Combined)	$5.0M	1.1% ($5.0M/$449.2M)	QoQ -47.62% (-$4.5M) YoY -45.20% (-$4.1M)
PALVELLA THERAPEUTICS, INC.(PVLAcusip697947109)	172.4K	QoQ NEW(+172.4K) YoY NEW(+172.4K)	All Managers (Combined)	$4.8M	1.1% ($4.8M/$449.2M)	QoQ NEW(+$4.8M) YoY NEW(+$4.8M)
Gossamer Bio, Inc.(GOSScusip38341P102)	4.3M	QoQ -4.51% (-202.6K) YoY +75.70% (+1.8M)	All Managers (Combined)	$4.7M	1.1% ($4.7M/$449.2M)	QoQ +16.11% (-$654.5K) YoY +63.79% (+$1.8M)