Baker-Bros-Advisors-Lp

AI_NATIVE detailed information: This accession holds the following tickers:[
  "MRUS",
  "AKRO",
  "KNSA",
  "EWTX",
  "CNTA",
  "ALKS",
  "INSM",
  "RVMD",
  "ARGX",
  "ACAD",
  "MDGL",
  "ABCL",
  "PRME",
  "SKYE",
  "TCRX",
  "RCKT",
  "BCAX",
  "BCYC",
  "GPCR",
  "IMTX",
  "RLAY",
  "IGMS",
  "TSHA",
  "TYRA",
  "NRIX",
  "STOK",
  "ACRV",
  "SMMT",
  "TECX",
  "KYMR",
  "REPL",
  "NMRA",
  "GLUE",
  "NGNE",
  "TSVT",
  "ALMS",
  "ALGS",
  "CTNM",
  null,
  "FATE",
  "SANA",
  null,
  "KALA",
  "LPTX",
  "PRLD",
  "SGMT",
  "IONS",
  "TARA",
  null,
  "IDYA",
  "INCY",
  "SERA",
  "PRAX",
  "RGLS",
  "RYTM",
  "NTLA",
  "DYN",
  null,
  "GRAL",
  "WVE",
  "ROIV",
  "OPT",
  "ELVN",
  "GBIO",
  "IMCR",
  "HOOK",
  "DSGN",
  "KOD",
  "VRNA",
  "VERV",
  "VIR",
  "VTVT",
  "XENE",
  "TRDA",
  "XNCR",
  "RARE",
  "IMVT",
  "PCVX",
  null,
  "BNTX",
  "CADL",
  "CELC",
  "CLDX",
  "CERS",
  "IPSC",
  "CMPX",
  "CRSP",
  "DNLI",
  "IRON"
]

Filing Details

13F-HR • 2025-03-31

SEC FilingSEC DataHachi Filing

Report Date: 2025-03-31
Filing Date: 2025-05-15
Total Holdings: 89
Total Value: 9036702464
Accession Number: 0001104659-25-049518
Form Type: 13F-HR
CIK: baker-bros-advisors-lp
Manager Name: Baker-Bros-Advisors-Lp

Data Enrichment

94% identified

84 identified5 unidentified

Holdings

SEC FilingSEC DataHachi Filing

Manager:

89 positions • $9.0B total value

SEC FilingSEC DataHachi Filing

Manager:

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07725L102

Shares:8.8M

Value:$2.4B

% of Portfolio:26.5% ($2.4B/$9.0B)

INCYTE CORP

INCY|45337C102

Shares:30.7M

Value:$1.9B

% of Portfolio:20.6% ($1.9B/$9.0B)

ACADIA PHARMACEUTICALS INC

ACAD|004225108

Shares:42.9M

Value:$712.2M

% of Portfolio:7.9% ($712.2M/$9.0B)

MADRIGAL PHARMACEUTICALS, INC.

MDGL|558868105

Shares:2.0M

Value:$654.0M

% of Portfolio:7.2% ($654.0M/$9.0B)

Summit Therapeutics Inc.

SMMT|86627T108

Shares:24.4M

Value:$471.2M

% of Portfolio:5.2% ($471.2M/$9.0B)

INSMED Inc

INSM|457669307

Shares:5.4M

Value:$410.5M

% of Portfolio:4.5% ($410.5M/$9.0B)

RHYTHM PHARMACEUTICALS, INC.

RYTM|76243J105

Shares:5.6M

Value:$296.9M

% of Portfolio:3.3% ($296.9M/$9.0B)

Revolution Medicines, Inc.

RVMD|76155X100

Shares:7.9M

Value:$280.7M

% of Portfolio:3.1% ($280.7M/$9.0B)

Kymera Therapeutics, Inc.

KYMR|501575104

Shares:6.0M

Value:$164.1M

% of Portfolio:1.8% ($164.1M/$9.0B)

Alkermes plc.

ALKS|G01767105

Shares:4.5M

Value:$148.0M

% of Portfolio:1.6% ($148.0M/$9.0B)

Edgewise Therapeutics, Inc.

EWTX|28036F105

Shares:6.2M

Value:$135.4M

% of Portfolio:1.5% ($135.4M/$9.0B)

Replimune Group, Inc.

REPL|76029N106

Shares:11.0M

Value:$107.7M

% of Portfolio:1.2% ($107.7M/$9.0B)

457669AB5

Shares:—

Value:$101.6M

% of Portfolio:1.1% ($101.6M/$9.0B)

Immunovant, Inc.

IMVT|45258J102

Shares:5.5M

Value:$93.3M

% of Portfolio:1.0% ($93.3M/$9.0B)

BICYCLE THERAPEUTICS PLC

BCYC|088786108

Shares:10.9M

Value:$92.4M

% of Portfolio:1.0% ($92.4M/$9.0B)

Immunocore Holdings plc

IMCR|45258D105

Shares:2.3M

Value:$68.9M

% of Portfolio:0.8% ($68.9M/$9.0B)

Kiniksa Pharmaceuticals International, plc

KNSA|G52694109

Shares:2.8M

Value:$62.6M

% of Portfolio:0.7% ($62.6M/$9.0B)

AbCellera Biologics Inc.

ABCL|00288U106

Shares:27.5M

Value:$61.4M

% of Portfolio:0.7% ($61.4M/$9.0B)

Ultragenyx Pharmaceutical Inc.

RARE|90400D108

Shares:1.6M

Value:$57.1M

% of Portfolio:0.6% ($57.1M/$9.0B)

Denali Therapeutics Inc.

DNLI|24823R105

Shares:3.7M

Value:$50.7M

% of Portfolio:0.6% ($50.7M/$9.0B)

Instrument	Shares		Other Manager	Value	% of Portfolio
(cusip07725L102)✕	8.8M	QoQ -7.68% (-732.8K) YoY -16.74% (-1.8M)	All Managers (Combined)	$2.4B	26.5% ($2.4B/$9.0B)	QoQ +36.02% (-$634.2M) YoY +44.88% (-$742.0M)
INCYTE CORP(INCYcusip45337C102)	30.7M	QoQ 0.00% (-487) YoY -15.03% (-5.4M)	All Managers (Combined)	$1.9B	20.6% ($1.9B/$9.0B)	QoQ -12.33% (-$261.9M) YoY -9.69% (-$199.9M)
ACADIA PHARMACEUTICALS INC(ACADcusip004225108)	42.9M	QoQ 0.00% (-0) YoY +0.03% (-13.3K)	All Managers (Combined)	$712.2M	7.9% ($712.2M/$9.0B)	QoQ -9.48% (-$74.6M) YoY -10.13% (-$80.4M)
MADRIGAL PHARMACEUTICALS, INC.(MDGLcusip558868105)	2.0M	QoQ 0.00% (+0) YoY +0.24% (+4.8K)	All Managers (Combined)	$654.0M	7.2% ($654.0M/$9.0B)	QoQ +7.34% (+$44.7M) YoY +24.33% (+$128.0M)
Summit Therapeutics Inc.(SMMTcusip86627T108)	24.4M	QoQ 0.00% (+0) YoY NEW(+24.4M)	All Managers (Combined)	$471.2M	5.2% ($471.2M/$9.0B)	QoQ +8.09% (+$35.3M) YoY NEW(+$471.2M)
INSMED Inc(INSMcusip457669307)	5.4M	QoQ +7.46% (+373.8K) YoY +1468.69% (+5.0M)	All Managers (Combined)	$410.5M	4.5% ($410.5M/$9.0B)	QoQ +18.75% (+$64.8M) YoY +4311.19% (+$401.2M)
RHYTHM PHARMACEUTICALS, INC.(RYTMcusip76243J105)	5.6M	QoQ -7.88% (-479.8K) YoY -12.40% (-793.9K)	All Managers (Combined)	$296.9M	3.3% ($296.9M/$9.0B)	QoQ -12.83% (-$43.7M) YoY +7.07% (-$19.6M)
Revolution Medicines, Inc.(RVMDcusip76155X100)	7.9M	QoQ 0.00% (-0) YoY +5.13% (+387.7K)	All Managers (Combined)	$280.7M	3.1% ($280.7M/$9.0B)	QoQ -19.15% (-$66.5M) YoY +15.34% (+$37.3M)
Kymera Therapeutics, Inc.(KYMRcusip501575104)	6.0M	QoQ 0.00% (-0) YoY 0.00% (-1)	All Managers (Combined)	$164.1M	1.8% ($164.1M/$9.0B)	QoQ -31.96% (-$77.1M) YoY -31.91% (-$76.9M)
Alkermes plc.(ALKScusipG01767105)	4.5M	QoQ +7.21% (+301.5K) YoY NEW(+4.5M)	All Managers (Combined)	$148.0M	1.6% ($148.0M/$9.0B)	QoQ +23.09% (+$27.8M) YoY NEW(+$148.0M)
Edgewise Therapeutics, Inc.(EWTXcusip28036F105)	6.2M	QoQ 0.00% (-0) YoY +5.40% (+315.9K)	All Managers (Combined)	$135.4M	1.5% ($135.4M/$9.0B)	QoQ -17.60% (-$28.9M) YoY +27.13% (+$28.9M)
Replimune Group, Inc.(REPLcusip76029N106)	11.0M	QoQ 0.00% (-0) YoY +15.71% (+1.5M)	All Managers (Combined)	$107.7M	1.2% ($107.7M/$9.0B)	QoQ -19.48% (-$26.1M) YoY +38.09% (+$29.7M)
(cusip457669AB5)✕	—	QoQ - YoY NEW	All Managers (Combined)	$101.6M	1.1% ($101.6M/$9.0B)	QoQ +9.31% (+$8.7M) YoY NEW(+$101.6M)
Immunovant, Inc.(IMVTcusip45258J102)	5.5M	QoQ +219.57% (+3.8M) YoY +1184.18% (+5.0M)	All Managers (Combined)	$93.3M	1.0% ($93.3M/$9.0B)	QoQ +120.48% (+$51.0M) YoY +579.25% (+$79.5M)
BICYCLE THERAPEUTICS PLC(BCYCcusip088786108)	10.9M	QoQ 0.00% (-0) YoY +120.22% (-5.9M)	All Managers (Combined)	$92.4M	1.0% ($92.4M/$9.0B)	QoQ -39.35% (-$60.0M) YoY -24.91% (-$30.7M)
Immunocore Holdings plc(IMCRcusip45258D105)	2.3M	QoQ +53.27% (+807.3K) YoY +53.27% (-807.3K)	All Managers (Combined)	$68.9M	0.8% ($68.9M/$9.0B)	QoQ +54.16% (+$24.2M) YoY -30.03% (-$29.6M)
Kiniksa Pharmaceuticals International, plc(KNSAcusipG52694109)	2.8M	QoQ 0.00% (+0) YoY NEW(+2.8M)	All Managers (Combined)	$62.6M	0.7% ($62.6M/$9.0B)	QoQ +12.28% (+$6.8M) YoY NEW(+$62.6M)
AbCellera Biologics Inc.(ABCLcusip00288U106)	27.5M	QoQ 0.00% (-0) YoY 0.00% (-0)	All Managers (Combined)	$61.4M	0.7% ($61.4M/$9.0B)	QoQ -23.89% (-$19.3M) YoY -50.77% (-$63.3M)
Ultragenyx Pharmaceutical Inc.(RAREcusip90400D108)	1.6M	QoQ 0.00% (-0) YoY +7.47% (-109.6K)	All Managers (Combined)	$57.1M	0.6% ($57.1M/$9.0B)	QoQ -13.92% (-$9.2M) YoY -16.65% (-$11.4M)
Denali Therapeutics Inc.(DNLIcusip24823R105)	3.7M	QoQ 0.00% (-0) YoY 0.00% (-0)	All Managers (Combined)	$50.7M	0.6% ($50.7M/$9.0B)	QoQ -33.29% (-$25.3M) YoY -33.74% (-$25.8M)