Baker-Bros-Advisors-Lp

AI_NATIVE detailed information: This accession holds the following tickers:[
  "MRUS",
  "AKRO",
  "KNSA",
  "EWTX",
  "CNTA",
  "ALKS",
  "INSM",
  "RVMD",
  "ARGX",
  "ACAD",
  "MDGL",
  "ABCL",
  "PRME",
  "SKYE",
  "TCRX",
  "RCKT",
  "BCAX",
  "BCYC",
  "GPCR",
  "IMTX",
  "RLAY",
  "IGMS",
  "TSHA",
  "TYRA",
  "NRIX",
  "STOK",
  "ACRV",
  "SMMT",
  "TECX",
  "KYMR",
  "REPL",
  "NMRA",
  "GLUE",
  "NGNE",
  "TSVT",
  "ALMS",
  "ALGS",
  "CTNM",
  null,
  "FATE",
  "SANA",
  null,
  "KALA",
  "LPTX",
  "PRLD",
  "SGMT",
  "IONS",
  "TARA",
  null,
  "IDYA",
  "INCY",
  "SERA",
  "PRAX",
  "RGLS",
  "RYTM",
  "NTLA",
  "DYN",
  null,
  "GRAL",
  "WVE",
  "ROIV",
  "OPT",
  "ELVN",
  "GBIO",
  "IMCR",
  "HOOK",
  "DSGN",
  "KOD",
  "VRNA",
  "VERV",
  "VIR",
  "VTVT",
  "XENE",
  "TRDA",
  "XNCR",
  "RARE",
  "IMVT",
  "PCVX",
  null,
  "BNTX",
  "CADL",
  "CELC",
  "CLDX",
  "CERS",
  "IPSC",
  "CMPX",
  "CRSP",
  "DNLI",
  "IRON"
]

Filing Details

13F-HR • 2025-03-31

SEC FilingSEC DataHachi Filing

Report Date: 2025-03-31
Filing Date: 2025-05-15
Total Holdings: 89
Total Value: 9036702464
Accession Number: 0001104659-25-049518
Form Type: 13F-HR
CIK: baker-bros-advisors-lp
Manager Name: Baker-Bros-Advisors-Lp

Data Enrichment

94% identified

84 identified5 unidentified

Holdings

SEC FilingSEC DataHachi Filing

Manager:

89 positions • $9.0B total value

SEC FilingSEC DataHachi Filing

Manager:

Search and click to pin securities to the top

Page 3 of 5

Sort by:

Praxis Precision Medicines, Inc.

PRAX|74006W207

Shares:331.5K

Value:$12.6M

% of Portfolio:0.1% ($12.6M/$9.0B)

2seventy bio, Inc.

TSVT|901384107

Shares:2.5M

Value:$12.3M

% of Portfolio:0.1% ($12.3M/$9.0B)

Xenon Pharmaceuticals Inc.

XENE|98420N105

Shares:347.4K

Value:$11.7M

% of Portfolio:0.1% ($11.7M/$9.0B)

Bicara Therapeutics Inc.

BCAX|055477103

Shares:833.3K

Value:$10.9M

% of Portfolio:0.1% ($10.9M/$9.0B)

IONIS PHARMACEUTICALS INC

IONS|462222100

Shares:357.9K

Value:$10.8M

% of Portfolio:0.1% ($10.8M/$9.0B)

23306J309

Shares:1.5M

Value:$10.0M

% of Portfolio:0.1% ($10.0M/$9.0B)

ALUMIS INC.

ALMS|022307102

Shares:1.6M

Value:$9.6M

% of Portfolio:0.1% ($9.6M/$9.0B)

Merus N.V.

MRUS|N5749R100

Shares:223.5K

Value:$9.4M

% of Portfolio:0.1% ($9.4M/$9.0B)

Prelude Therapeutics Inc

PRLD|74065P101

Shares:10.1M

Value:$7.8M

% of Portfolio:0.1% ($7.8M/$9.0B)

Verve Therapeutics, Inc.

VERV|92539P101

Shares:1.7M

Value:$7.7M

% of Portfolio:0.1% ($7.7M/$9.0B)

ROCKET PHARMACEUTICALS, INC.

RCKT|77313F106

Shares:1.1M

Value:$7.3M

% of Portfolio:0.1% ($7.3M/$9.0B)

Xencor Inc

XNCR|98401F105

Shares:670.4K

Value:$7.1M

% of Portfolio:0.1% ($7.1M/$9.0B)

Dyne Therapeutics, Inc.

DYN|26818M108

Shares:672.1K

Value:$7.0M

% of Portfolio:0.1% ($7.0M/$9.0B)

KALA BIO, Inc.

KALA|483119202

Shares:1.2M

Value:$6.9M

% of Portfolio:0.1% ($6.9M/$9.0B)

Design Therapeutics, Inc.

DSGN|25056L103

Shares:1.7M

Value:$6.7M

% of Portfolio:0.1% ($6.7M/$9.0B)

Structure Therapeutics Inc.

GPCR|86366E106

Shares:361.6K

Value:$6.3M

% of Portfolio:0.1% ($6.3M/$9.0B)

Taysha Gene Therapies, Inc.

TSHA|877619106

Shares:4.0M

Value:$5.6M

% of Portfolio:0.1% ($5.6M/$9.0B)

Regulus Therapeutics Inc.

RGLS|75915K309

Shares:2.7M

Value:$4.7M

% of Portfolio:0.1% ($4.7M/$9.0B)

IGM Biosciences, Inc.

IGMS|449585108

Shares:4.1M

Value:$4.7M

% of Portfolio:0.1% ($4.7M/$9.0B)

Intellia Therapeutics, Inc.

NTLA|45826J105

Shares:644.1K

Value:$4.6M

% of Portfolio:0.1% ($4.6M/$9.0B)

Instrument	Shares		Other Manager	Value	% of Portfolio
Praxis Precision Medicines, Inc.(PRAXcusip74006W207)	331.5K	QoQ 0.00% (-0) YoY +152.05% (+200.0K)	All Managers (Combined)	$12.6M	0.1% ($12.6M/$9.0B)	QoQ -50.79% (-$13.0M) YoY +56.42% (+$4.5M)
2seventy bio, Inc.(TSVTcusip901384107)	2.5M	QoQ 0.00% (+0) YoY 0.00% (-0)	All Managers (Combined)	$12.3M	0.1% ($12.3M/$9.0B)	QoQ +68.02% (+$5.0M) YoY -7.66% (-$1.0M)
Xenon Pharmaceuticals Inc.(XENEcusip98420N105)	347.4K	QoQ -65.03% (-646.3K) YoY -65.03% (-646.3K)	All Managers (Combined)	$11.7M	0.1% ($11.7M/$9.0B)	QoQ -70.07% (-$27.3M) YoY -72.75% (-$31.1M)
Bicara Therapeutics Inc.(BCAXcusip055477103)	833.3K	QoQ 0.00% (-0) YoY NEW(+833.3K)	All Managers (Combined)	$10.9M	0.1% ($10.9M/$9.0B)	QoQ -25.20% (-$3.7M) YoY NEW(+$10.9M)
IONIS PHARMACEUTICALS INC(IONScusip462222100)	357.9K	QoQ 0.00% (-0) YoY NEW(+357.9K)	All Managers (Combined)	$10.8M	0.1% ($10.8M/$9.0B)	QoQ -13.70% (-$1.7M) YoY NEW(+$10.8M)
(cusip23306J309)✕	1.5M	QoQ 0.00% (+0) YoY NEW(+1.5M)	All Managers (Combined)	$10.0M	0.1% ($10.0M/$9.0B)	QoQ +120.71% (+$5.5M) YoY NEW(+$10.0M)
ALUMIS INC.(ALMScusip022307102)	1.6M	QoQ 0.00% (-0) YoY NEW(+1.6M)	All Managers (Combined)	$9.6M	0.1% ($9.6M/$9.0B)	QoQ -21.88% (-$2.7M) YoY NEW(+$9.6M)
Merus N.V.(MRUScusipN5749R100)	223.5K	QoQ -50.33% (-226.5K) YoY NEW(+223.5K)	All Managers (Combined)	$9.4M	0.1% ($9.4M/$9.0B)	QoQ -50.28% (-$9.5M) YoY NEW(+$9.4M)
Prelude Therapeutics Inc(PRLDcusip74065P101)	10.1M	QoQ 0.00% (-0) YoY 0.00% (-0)	All Managers (Combined)	$7.8M	0.1% ($7.8M/$9.0B)	QoQ -39.76% (-$5.1M) YoY -83.79% (-$40.2M)
Verve Therapeutics, Inc.(VERVcusip92539P101)	1.7M	QoQ 0.00% (-0) YoY 0.00% (-0)	All Managers (Combined)	$7.7M	0.1% ($7.7M/$9.0B)	QoQ -18.97% (-$1.8M) YoY -65.58% (-$14.7M)
ROCKET PHARMACEUTICALS, INC.(RCKTcusip77313F106)	1.1M	QoQ +1030.08% (+1.0M) YoY NEW(+1.1M)	All Managers (Combined)	$7.3M	0.1% ($7.3M/$9.0B)	QoQ +499.65% (+$6.1M) YoY NEW(+$7.3M)
Xencor Inc(XNCRcusip98401F105)	670.4K	QoQ 0.00% (-0) YoY +22.91% (-125.0K)	All Managers (Combined)	$7.1M	0.1% ($7.1M/$9.0B)	QoQ -53.69% (-$8.3M) YoY -40.90% (-$4.9M)
Dyne Therapeutics, Inc.(DYNcusip26818M108)	672.1K	QoQ 0.00% (-0) YoY +135.82% (-387.1K)	All Managers (Combined)	$7.0M	0.1% ($7.0M/$9.0B)	QoQ -55.60% (-$8.8M) YoY -13.11% (-$1.1M)
KALA BIO, Inc.(KALAcusip483119202)	1.2M	QoQ 0.00% (-0) YoY +350.80% (+935.3K)	All Managers (Combined)	$6.9M	0.1% ($6.9M/$9.0B)	QoQ -17.43% (-$1.5M) YoY +224.10% (+$4.8M)
Design Therapeutics, Inc.(DSGNcusip25056L103)	1.7M	QoQ 0.00% (-0) YoY +4.90% (+81.6K)	All Managers (Combined)	$6.7M	0.1% ($6.7M/$9.0B)	QoQ -37.43% (-$4.0M) YoY +0.48% (+$32.4K)
Structure Therapeutics Inc.(GPCRcusip86366E106)	361.6K	QoQ 0.00% (-0) YoY NEW(+361.6K)	All Managers (Combined)	$6.3M	0.1% ($6.3M/$9.0B)	QoQ -36.17% (-$3.5M) YoY NEW(+$6.3M)
Taysha Gene Therapies, Inc.(TSHAcusip877619106)	4.0M	QoQ 0.00% (-0) YoY 0.00% (-0)	All Managers (Combined)	$5.6M	0.1% ($5.6M/$9.0B)	QoQ -19.65% (-$1.4M) YoY -51.56% (-$5.9M)
Regulus Therapeutics Inc.(RGLScusip75915K309)	2.7M	QoQ NEW(+2.7M) YoY NEW(+2.7M)	All Managers (Combined)	$4.7M	0.1% ($4.7M/$9.0B)	QoQ NEW(+$4.7M) YoY NEW(+$4.7M)
IGM Biosciences, Inc.(IGMScusip449585108)	4.1M	QoQ +0.02% (-953) YoY +0.16% (-6.9K)	All Managers (Combined)	$4.7M	0.1% ($4.7M/$9.0B)	QoQ -81.17% (-$20.3M) YoY -88.06% (-$34.7M)
Intellia Therapeutics, Inc.(NTLAcusip45826J105)	644.1K	QoQ 0.00% (-0) YoY NEW(+644.1K)	All Managers (Combined)	$4.6M	0.1% ($4.6M/$9.0B)	QoQ -39.02% (-$2.9M) YoY NEW(+$4.6M)