Baker Bros. Advisors LP

Filing Details

13F-HR • 2025-03-31

SEC FilingSEC DataHachi Filing

Report Date: 2025-03-31
Filing Date: 2025-05-15
Total Holdings: 89
Total Value: 9036702464
Accession Number: 0001104659-25-049518
Form Type: 13F-HR
CIK: 0001263508
Manager Name: Baker Bros. Advisors LP

Data Enrichment

94% identified

84 identified5 unidentified

Holdings

SEC FilingSEC DataHachi Filing

Manager:

89 positions • $9,036,702.464K total value

89 positions

Manager:

SEC FilingSEC DataHachi Filing

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Praxis Precision Medicines, Inc.

PRAX|74006W207

331533(+0.0%)

Value:

$12.6B(-50.8%)

2seventy bio, Inc.

TSVT|901384107

2497526(+0.0%)

Value:

$12.3B(+68.0%)

Xenon Pharmaceuticals Inc.

XENE|98420N105

347408(-65.0%)

Value:

$11.7B(-70.1%)

Bicara Therapeutics Inc.

BCAX|055477103

833333(+0.0%)

Value:

$10.9B(-25.2%)

IONIS PHARMACEUTICALS INC

IONS|462222100

357915(+0.0%)

Value:

$10.8B(-13.7%)

23306J309

1461425(+0.0%)

Value:

$10.0B(+120.7%)

ALUMIS INC.

ALMS|022307102

1562500(+0.0%)

Value:

$9.6B(-21.9%)

Merus N.V.

MRUS|N5749R100

223500(-50.3%)

Value:

$9.4B(-50.3%)

Prelude Therapeutics Inc

PRLD|74065P101

10123824(+0.0%)

Value:

$7.8B(-39.8%)

Verve Therapeutics, Inc.

VERV|92539P101

1691530(+0.0%)

Value:

$7.7B(-19.0%)

ROCKET PHARMACEUTICALS, INC.

RCKT|77313F106

1097079(+1030.1%)

Value:

$7.3B(+499.6%)

Xencor Inc

XNCR|98401F105

670431(+0.0%)

Value:

$7.1B(-53.7%)

Dyne Therapeutics, Inc.

DYN|26818M108

672096(+0.0%)

Value:

$7.0B(-55.6%)

KALA BIO, Inc.

KALA|483119202

1201894(+0.0%)

Value:

$6.9B(-17.4%)

Design Therapeutics, Inc.

DSGN|25056L103

1743725(+0.0%)

Value:

$6.7B(-37.4%)

Structure Therapeutics Inc.

GPCR|86366E106

361565(+0.0%)

Value:

$6.3B(-36.2%)

Taysha Gene Therapies, Inc.

TSHA|877619106

4004756(+0.0%)

Value:

$5.6B(-19.6%)

Regulus Therapeutics Inc.

RGLS|75915K309

2694044

Value:

$4.7B

IGM Biosciences, Inc.

IGMS|449585108

4095257(+0.0%)

Value:

$4.7B(-81.2%)

Intellia Therapeutics, Inc.

NTLA|45826J105

644116(+0.0%)

Value:

$4.6B(-39.0%)

Instrument	Shares		Other Manager	Value
Praxis Precision Medicines, Inc.(PRAXcusip74006W207)	331.5K	QoQ 0.00% (-0) YoY +152.05% (+200.0K)	All Managers (Combined)	$12.6M	QoQ -50.79% (-$13.0M) YoY +56.42% (+$4.5M)
2seventy Bio, Inc.(TSVTcusip901384107)	2.5M	QoQ 0.00% (+0) YoY 0.00% (-0)	All Managers (Combined)	$12.3M	QoQ +68.02% (+$5.0M) YoY -7.66% (-$1.0M)
Xenon Pharmaceuticals Inc.(XENEcusip98420N105)	347.4K	QoQ -65.03% (-646.3K) YoY -65.03% (-646.3K)	All Managers (Combined)	$11.7M	QoQ -70.07% (-$27.3M) YoY -72.75% (-$31.1M)
Bicara Therapeutics Inc.(BCAXcusip055477103)	833.3K	QoQ 0.00% (-0) YoY NEW(+833.3K)	All Managers (Combined)	$10.9M	QoQ -25.20% (-$3.7M) YoY NEW(+$10.9M)
Ionis Pharmaceuticals Inc(IONScusip462222100)	357.9K	QoQ 0.00% (-0) YoY NEW(+357.9K)	All Managers (Combined)	$10.8M	QoQ -13.70% (-$1.7M) YoY NEW(+$10.8M)
(cusip23306J309)✕	1.5M	QoQ 0.00% (+0) YoY NEW(+1.5M)	All Managers (Combined)	$10.0M	QoQ +120.71% (+$5.5M) YoY NEW(+$10.0M)
Alumis Inc.(ALMScusip022307102)	1.6M	QoQ 0.00% (-0) YoY NEW(+1.6M)	All Managers (Combined)	$9.6M	QoQ -21.88% (-$2.7M) YoY NEW(+$9.6M)
Merus N.V.(MRUScusipN5749R100)	223.5K	QoQ -50.33% (-226.5K) YoY NEW(+223.5K)	All Managers (Combined)	$9.4M	QoQ -50.28% (-$9.5M) YoY NEW(+$9.4M)
Prelude Therapeutics Inc(PRLDcusip74065P101)	10.1M	QoQ 0.00% (-0) YoY 0.00% (-0)	All Managers (Combined)	$7.8M	QoQ -39.76% (-$5.1M) YoY -83.79% (-$40.2M)
Verve Therapeutics, Inc.(VERVcusip92539P101)	1.7M	QoQ 0.00% (-0) YoY 0.00% (-0)	All Managers (Combined)	$7.7M	QoQ -18.97% (-$1.8M) YoY -65.58% (-$14.7M)
Rocket Pharmaceuticals, Inc.(RCKTcusip77313F106)	1.1M	QoQ +1030.08% (+1.0M) YoY NEW(+1.1M)	All Managers (Combined)	$7.3M	QoQ +499.65% (+$6.1M) YoY NEW(+$7.3M)
Xencor Inc(XNCRcusip98401F105)	670.4K	QoQ 0.00% (-0) YoY +22.91% (-125.0K)	All Managers (Combined)	$7.1M	QoQ -53.69% (-$8.3M) YoY -40.90% (-$4.9M)
Dyne Therapeutics, Inc.(DYNcusip26818M108)	672.1K	QoQ 0.00% (-0) YoY +135.82% (-387.1K)	All Managers (Combined)	$7.0M	QoQ -55.60% (-$8.8M) YoY -13.11% (-$1.1M)
Kala Bio, Inc.(KALAcusip483119202)	1.2M	QoQ 0.00% (-0) YoY +350.80% (+935.3K)	All Managers (Combined)	$6.9M	QoQ -17.43% (-$1.5M) YoY +224.10% (+$4.8M)
Design Therapeutics, Inc.(DSGNcusip25056L103)	1.7M	QoQ 0.00% (-0) YoY +4.90% (+81.6K)	All Managers (Combined)	$6.7M	QoQ -37.43% (-$4.0M) YoY +0.48% (+$32.4K)
Structure Therapeutics Inc.(GPCRcusip86366E106)	361.6K	QoQ 0.00% (-0) YoY NEW(+361.6K)	All Managers (Combined)	$6.3M	QoQ -36.17% (-$3.5M) YoY NEW(+$6.3M)
Taysha Gene Therapies, Inc.(TSHAcusip877619106)	4.0M	QoQ 0.00% (-0) YoY 0.00% (-0)	All Managers (Combined)	$5.6M	QoQ -19.65% (-$1.4M) YoY -51.56% (-$5.9M)
Regulus Therapeutics Inc.(RGLScusip75915K309)	2.7M	QoQ NEW(+2.7M) YoY NEW(+2.7M)	All Managers (Combined)	$4.7M	QoQ NEW(+$4.7M) YoY NEW(+$4.7M)
Igm Biosciences, Inc.(IGMScusip449585108)	4.1M	QoQ +0.02% (-953) YoY +0.16% (-6.9K)	All Managers (Combined)	$4.7M	QoQ -81.17% (-$20.3M) YoY -88.06% (-$34.7M)
Intellia Therapeutics, Inc.(NTLAcusip45826J105)	644.1K	QoQ 0.00% (-0) YoY NEW(+644.1K)	All Managers (Combined)	$4.6M	QoQ -39.02% (-$2.9M) YoY NEW(+$4.6M)