Siren

AI_NATIVE detailed information: This accession holds the following tickers:[
  "MRUS",
  "ASND",
  "EWTX",
  "TRVI",
  "CNTA",
  "NAMS",
  "RVMD",
  "ORIC",
  "TIL",
  "PCOR",
  "INFA",
  "EDU",
  "FROG",
  "ADBE",
  "APLS",
  "ARWR",
  "GOOGL",
  "GDS",
  "CRBU",
  "DT",
  "RCKT",
  "BCAX",
  "BCYC",
  "RCUS",
  "TNGX",
  "SLN",
  "RAPP",
  "IGMS",
  "TSHA",
  "TRML",
  "STOK",
  "SMMT",
  "KYMR",
  "NMRA",
  "PRTA",
  "AGEN",
  "BIOA",
  "QCOM",
  "SRRK",
  "SYRE",
  "APGE",
  "KRRO",
  "LXEO",
  null,
  "PRQR",
  "SEER",
  "SGMT",
  "SEMR",
  "SEPN",
  "SARO",
  "WHWK",
  "IONQ",
  "CYCN",
  "MRVL",
  "MSFT",
  "OXY",
  "PANW",
  "PYPL",
  "NVDA",
  "INTC",
  "LPLA",
  "MDB",
  "RELY",
  "NOW",
  "UPB",
  null,
  "RNA",
  "TBLA",
  "SLDB",
  "LXRX",
  "RYTM",
  "SLNO",
  "RNAC",
  "DYN",
  null,
  "GOSS",
  "TSM",
  "WVE",
  "DECK",
  "ELDN",
  "ERAS",
  "GBIO",
  "IHS",
  "HOOK",
  "KLRS",
  "IRWD",
  "KRON",
  "RACE",
  "AMZN",
  "BEKE",
  "PDD",
  "USB",
  "VIGL",
  "WK",
  "XENE",
  null,
  "FHTX",
  "VERA",
  "CRM",
  "RDDT",
  "PEGA",
  "PCVX",
  null,
  "BDTX",
  "BILL",
  "BPMC",
  "BA",
  "BASE",
  "CRNX",
  "CRWD",
  "CGEM",
  "DDOG",
  "DNLI",
  "IRON",
  "NKE",
  "TSLA"
]

Filing Details

13F-HR/A • 2025-03-31

SEC FilingSEC DataHachi Filing

Report Date: 2025-03-31
Filing Date: 2025-05-23
Total Holdings: 117
Total Value: 1772780355
Accession Number: 0002005245-25-000008
Form Type: 13F-HR/A
CIK: siren
Manager Name: Siren

Data Enrichment

96% identified

112 identified5 unidentified

Holdings

SEC FilingSEC DataHachi Filing

Manager:

117 positions • $1.8B total value

SEC FilingSEC DataHachi Filing

Manager:

Search and click to pin securities to the top

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Xenon Pharmaceuticals Inc.

XENE|98420N105

Shares:732.8K

Value:$24.6M

% of Portfolio:1.4% ($24.6M/$1.8B)

Apogee Therapeutics, Inc.

APGE|03770N101

Shares:595.0K

Value:$22.2M

% of Portfolio:1.3% ($22.2M/$1.8B)

Revolution Medicines, Inc.

RVMD|76155X100

Shares:563.8K

Value:$19.9M

% of Portfolio:1.1% ($19.9M/$1.8B)

Trevi Therapeutics, Inc.

TRVI|89532M101

Shares:2.9M

Value:$18.0M

% of Portfolio:1.0% ($18.0M/$1.8B)

Vera Therapeutics, Inc.

VERA|92337R101

Shares:747.2K

Value:$17.9M

% of Portfolio:1.0% ($17.9M/$1.8B)

LEXICON PHARMACEUTICALS, INC.

LXRX|528872302

Shares:38.9M

Value:$17.9M

% of Portfolio:1.0% ($17.9M/$1.8B)

PROTHENA CORP PUBLIC LTD CO

PRTA|G72800108

Shares:1.3M

Value:$15.9M

% of Portfolio:0.9% ($15.9M/$1.8B)

BICYCLE THERAPEUTICS PLC

BCYC|088786108

Shares:1.8M

Value:$15.4M

% of Portfolio:0.9% ($15.4M/$1.8B)

Stoke Therapeutics, Inc.

STOK|86150R107

Shares:2.2M

Value:$14.9M

% of Portfolio:0.8% ($14.9M/$1.8B)

RHYTHM PHARMACEUTICALS, INC.

RYTM|76243J105

Shares:277.5K

Value:$14.7M

% of Portfolio:0.8% ($14.7M/$1.8B)

Summit Therapeutics Inc.

SMMT|86627T108

Shares:695.0K

Value:$13.4M

% of Portfolio:0.8% ($13.4M/$1.8B)

Septerna, Inc.

SEPN|81734D104

Shares:2.2M

Value:$12.8M

% of Portfolio:0.7% ($12.8M/$1.8B)

Arcus Biosciences, Inc.

RCUS|03969F109

Shares:1.6M

Value:$12.7M

% of Portfolio:0.7% ($12.7M/$1.8B)

IHS Holding Ltd

IHS|G4701H109

Shares:2.4M

Value:$12.3M

% of Portfolio:0.7% ($12.3M/$1.8B)

Erasca, Inc.

ERAS|29479A108

Shares:8.8M

Value:$12.0M

% of Portfolio:0.7% ($12.0M/$1.8B)

Denali Therapeutics Inc.

DNLI|24823R105

Shares:821.5K

Value:$11.2M

% of Portfolio:0.6% ($11.2M/$1.8B)

Vaxcyte, Inc.

PCVX|92243G108

Shares:295.5K

Value:$11.2M

% of Portfolio:0.6% ($11.2M/$1.8B)

AMAZON COM INC

AMZN|023135106

Shares:56.5K

Value:$10.7M

% of Portfolio:0.6% ($10.7M/$1.8B)

MICROSOFT CORP

MSFT|594918104

Shares:28.5K

Value:$10.7M

% of Portfolio:0.6% ($10.7M/$1.8B)

Remitly Global, Inc.

RELY|75960P104

Shares:490.4K

Value:$10.2M

% of Portfolio:0.6% ($10.2M/$1.8B)

Instrument	Shares		Other Manager	Value	% of Portfolio
Xenon Pharmaceuticals Inc.(XENEcusip98420N105)	732.8K	QoQ -1.48% (-11.0K) YoY-	All Managers (Combined)	$24.6M	1.4% ($24.6M/$1.8B)	QoQ -15.67% (-$4.6M) YoY-
Apogee Therapeutics, Inc.(APGEcusip03770N101)	595.0K	QoQ -20.38% (-152.3K) YoY-	All Managers (Combined)	$22.2M	1.3% ($22.2M/$1.8B)	QoQ -34.33% (-$11.6M) YoY-
Revolution Medicines, Inc.(RVMDcusip76155X100)	563.8K	QoQ -1.36% (-7.8K) YoY-	All Managers (Combined)	$19.9M	1.1% ($19.9M/$1.8B)	QoQ -20.26% (-$5.1M) YoY-
Trevi Therapeutics, Inc.(TRVIcusip89532M101)	2.9M	QoQ -1.45% (-42.3K) YoY-	All Managers (Combined)	$18.0M	1.0% ($18.0M/$1.8B)	QoQ +50.44% (-$6.0M) YoY-
Vera Therapeutics, Inc.(VERAcusip92337R101)	747.2K	QoQ -1.48% (-11.2K) YoY-	All Managers (Combined)	$17.9M	1.0% ($17.9M/$1.8B)	QoQ -44.04% (-$14.1M) YoY-
LEXICON PHARMACEUTICALS, INC.(LXRXcusip528872302)	38.9M	QoQ 0.00% (-0) YoY-	All Managers (Combined)	$17.9M	1.0% ($17.9M/$1.8B)	QoQ -37.72% (-$10.9M) YoY-
PROTHENA CORP PUBLIC LTD CO(PRTAcusipG72800108)	1.3M	QoQ +16.70% (+183.7K) YoY-	All Managers (Combined)	$15.9M	0.9% ($15.9M/$1.8B)	QoQ +4.27% (+$651.2K) YoY-
BICYCLE THERAPEUTICS PLC(BCYCcusip088786108)	1.8M	QoQ -1.44% (-26.6K) YoY-	All Managers (Combined)	$15.4M	0.9% ($15.4M/$1.8B)	QoQ -40.23% (-$10.4M) YoY-
Stoke Therapeutics, Inc.(STOKcusip86150R107)	2.2M	QoQ +12.36% (-247.3K) YoY-	All Managers (Combined)	$14.9M	0.8% ($14.9M/$1.8B)	QoQ -32.25% (-$7.1M) YoY-
RHYTHM PHARMACEUTICALS, INC.(RYTMcusip76243J105)	277.5K	QoQ NEW(+277.5K) YoY-	All Managers (Combined)	$14.7M	0.8% ($14.7M/$1.8B)	QoQ NEW(+$14.7M) YoY-
Summit Therapeutics Inc.(SMMTcusip86627T108)	695.0K	QoQ NEW(+695.0K) YoY-	All Managers (Combined)	$13.4M	0.8% ($13.4M/$1.8B)	QoQ NEW(+$13.4M) YoY-
Septerna, Inc.(SEPNcusip81734D104)	2.2M	QoQ 0.00% (-0) YoY-	All Managers (Combined)	$12.8M	0.7% ($12.8M/$1.8B)	QoQ -74.71% (-$37.7M) YoY-
Arcus Biosciences, Inc.(RCUScusip03969F109)	1.6M	QoQ 0.00% (-0) YoY-	All Managers (Combined)	$12.7M	0.7% ($12.7M/$1.8B)	QoQ -47.28% (-$11.3M) YoY-
IHS Holding Ltd(IHScusipG4701H109)	2.4M	QoQ 0.00% (+0) YoY-	All Managers (Combined)	$12.3M	0.7% ($12.3M/$1.8B)	QoQ +78.76% (+$5.4M) YoY-
Erasca, Inc.(ERAScusip29479A108)	8.8M	QoQ -1.12% (-99.9K) YoY-	All Managers (Combined)	$12.0M	0.7% ($12.0M/$1.8B)	QoQ -46.03% (-$10.2M) YoY-
Denali Therapeutics Inc.(DNLIcusip24823R105)	821.5K	QoQ -1.50% (-12.5K) YoY-	All Managers (Combined)	$11.2M	0.6% ($11.2M/$1.8B)	QoQ -34.29% (-$5.8M) YoY-
Vaxcyte, Inc.(PCVXcusip92243G108)	295.5K	QoQ -1.48% (-4.4K) YoY-	All Managers (Combined)	$11.2M	0.6% ($11.2M/$1.8B)	QoQ -54.55% (-$13.4M) YoY-
AMAZON COM INC(AMZNcusip023135106)	56.5K	QoQ +54.79% (+20.0K) YoY-	All Managers (Combined)	$10.7M	0.6% ($10.7M/$1.8B)	QoQ +34.24% (+$2.7M) YoY-
MICROSOFT CORP(MSFTcusip594918104)	28.5K	QoQ +23.91% (+5.5K) YoY-	All Managers (Combined)	$10.7M	0.6% ($10.7M/$1.8B)	QoQ +10.35% (+$1.0M) YoY-
Remitly Global, Inc.(RELYcusip75960P104)	490.4K	QoQ 0.00% (-0) YoY-	All Managers (Combined)	$10.2M	0.6% ($10.2M/$1.8B)	QoQ -7.84% (-$868.1K) YoY-