Siren, L.l.c.

Investment Portfolio & 13F Holdings Analysis

About

Siren, L.L.C. is an institutional investment manager that filed its latest Form 13F for 2025Q1, reporting 117 holdings worth $1.8 billion. Form 13F filings provide transparency into the equity holdings of institutional investment managers with over $100 million in assets under management. This page displays the most recent portfolio holdings, allowing investors to track position changes, new investments, and portfolio composition.

AI_NATIVE detailed information: This accession holds the following tickers:[
  "MRUS",
  "ASND",
  "EWTX",
  "TRVI",
  "CNTA",
  "NAMS",
  "RVMD",
  "ORIC",
  "TIL",
  "PCOR",
  "INFA",
  "EDU",
  "FROG",
  "ADBE",
  "APLS",
  "ARWR",
  "GOOGL",
  "GDS",
  "CRBU",
  "DT",
  "RCKT",
  "BCAX",
  "BCYC",
  "RCUS",
  "TNGX",
  "SLN",
  "RAPP",
  "IGMS",
  "TSHA",
  "TRML",
  "STOK",
  "SMMT",
  "KYMR",
  "NMRA",
  "PRTA",
  "AGEN",
  "BIOA",
  "QCOM",
  "SRRK",
  "SYRE",
  "APGE",
  "KRRO",
  "LXEO",
  null,
  "PRQR",
  "SEER",
  "SGMT",
  "SEMR",
  "SEPN",
  "SARO",
  "WHWK",
  "IONQ",
  "CYCN",
  "MRVL",
  "MSFT",
  "OXY",
  "PANW",
  "PYPL",
  "NVDA",
  "INTC",
  "LPLA",
  "MDB",
  "RELY",
  "NOW",
  "UPB",
  null,
  "RNA",
  "TBLA",
  "SLDB",
  "LXRX",
  "RYTM",
  "SLNO",
  "RNAC",
  "DYN",
  null,
  "GOSS",
  "TSM",
  "WVE",
  "DECK",
  "ELDN",
  "ERAS",
  "GBIO",
  "IHS",
  "HOOK",
  "KLRS",
  "IRWD",
  "KRON",
  "RACE",
  "AMZN",
  "BEKE",
  "PDD",
  "USB",
  "VIGL",
  "WK",
  "XENE",
  null,
  "FHTX",
  "VERA",
  "CRM",
  "RDDT",
  "PEGA",
  "PCVX",
  null,
  "BDTX",
  "BILL",
  "BPMC",
  "BA",
  "BASE",
  "CRNX",
  "CRWD",
  "CGEM",
  "DDOG",
  "DNLI",
  "IRON",
  "NKE",
  "TSLA"
]

Filing Details

13F-HR/A • 2025-03-31

SEC FilingSEC DataHachi Filing

Report Date: 2025-03-31
Filing Date: 2025-05-23
Total Holdings: 117
Total Value: 1772780355
Accession Number: 0002005245-25-000008
Form Type: 13F-HR/A
CIK: siren
Manager Name: Siren

Data Enrichment

96% identified

112 identified5 unidentified

Holdings

SEC FilingSEC DataHachi Filing

Manager:

117 positions • $1,772,780.355K total value

117 positions

Manager:

SEC FilingSEC DataHachi Filing

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Scholar Rock Holding Corp

SRRK|80706P103

Shares:9.3M

Value:$297.4M

07725L102

Shares:498.7K

Value:$135.7M

Kymera Therapeutics, Inc.

KYMR|501575104

Shares:3.2M

Value:$88.7M

Blueprint Medicines Corp

BPMC|09627Y109

Shares:726.2K

Value:$64.3M

Crinetics Pharmaceuticals, Inc.

CRNX|22663K107

Shares:1.7M

Value:$56.6M

Apellis Pharmaceuticals, Inc.

APLS|03753U106

Shares:2.6M

Value:$56.4M

Disc Medicine, Inc.

IRON|254604101

Shares:1.1M

Value:$53.2M

SOLENO THERAPEUTICS INC

SLNO|834203309

Shares:727.3K

Value:$52.0M

Ascendis Pharma A/S

ASND|04351P101

Shares:287.4K

Value:$44.8M

Merus N.V.

MRUS|N5749R100

Shares:1.0M

Value:$43.9M

Bicara Therapeutics Inc.

BCAX|055477103

Shares:3.3M

Value:$42.6M

Centessa Pharmaceuticals plc

CNTA|152309100

Shares:3.0M

Value:$42.6M

NewAmsterdam Pharma Co N.V.

NAMS|N62509109

Shares:1.9M

Value:$39.1M

Edgewise Therapeutics, Inc.

EWTX|28036F105

Shares:1.7M

Value:$37.3M

ARROWHEAD PHARMACEUTICALS, INC.

ARWR|04280A100

Shares:2.7M

Value:$34.0M

Avidity Biosciences, Inc.

RNA|05370A108

Shares:1.1M

Value:$32.8M

Wave Life Sciences Ltd.

WVE|Y95308105

Shares:3.7M

Value:$29.9M

Taboola.com Ltd.

TBLA|M8744T106

Shares:10.0M

Value:$29.4M

Dyne Therapeutics, Inc.

DYN|26818M108

Shares:2.7M

Value:$28.4M

Solid Biosciences Inc.

SLDB|83422E204

Shares:7.4M

Value:$27.4M

Instrument	Shares		Other Manager	Value
Scholar Rock Holding Corp(SRRKcusip80706P103)	9.3M	QoQ 0.00% (-0) YoY-	All Managers (Combined)	$297.4M	QoQ -25.61% (-$102.4M) YoY-
(cusip07725L102)✕	498.7K	QoQ -23.71% (-155.0K) YoY-	All Managers (Combined)	$135.7M	QoQ +12.40% (-$15.0M) YoY-
Kymera Therapeutics, Inc.(KYMRcusip501575104)	3.2M	QoQ +9.11% (-270.6K) YoY-	All Managers (Combined)	$88.7M	QoQ -25.76% (-$30.8M) YoY-
Blueprint Medicines Corp(BPMCcusip09627Y109)	726.2K	QoQ NEW(+726.2K) YoY-	All Managers (Combined)	$64.3M	QoQ NEW(+$64.3M) YoY-
Crinetics Pharmaceuticals, Inc.(CRNXcusip22663K107)	1.7M	QoQ +4.90% (-79.0K) YoY-	All Managers (Combined)	$56.6M	QoQ -31.18% (-$25.7M) YoY-
Apellis Pharmaceuticals, Inc.(APLScusip03753U106)	2.6M	QoQ -8.44% (-237.9K) YoY-	All Managers (Combined)	$56.4M	QoQ -37.25% (-$33.5M) YoY-
Disc Medicine, Inc.(IRONcusip254604101)	1.1M	QoQ NEW(+1.1M) YoY-	All Managers (Combined)	$53.2M	QoQ NEW(+$53.2M) YoY-
SOLENO THERAPEUTICS INC(SLNOcusip834203309)	727.3K	QoQ +106.73% (+375.5K) YoY-	All Managers (Combined)	$52.0M	QoQ +228.61% (+$36.2M) YoY-
Ascendis Pharma A/S(ASNDcusip04351P101)	287.4K	QoQ -3.34% (-10.0K) YoY-	All Managers (Combined)	$44.8M	QoQ +9.42% (-$3.9M) YoY-
Merus N.V.(MRUScusipN5749R100)	1.0M	QoQ +33.02% (+259.1K) YoY-	All Managers (Combined)	$43.9M	QoQ +33.15% (+$10.9M) YoY-
Bicara Therapeutics Inc.(BCAXcusip055477103)	3.3M	QoQ -0.17% (-5.7K) YoY-	All Managers (Combined)	$42.6M	QoQ -25.33% (-$14.4M) YoY-
Centessa Pharmaceuticals plc(CNTAcusip152309100)	3.0M	QoQ -1.48% (-44.6K) YoY-	All Managers (Combined)	$42.6M	QoQ -15.42% (-$7.8M) YoY-
NewAmsterdam Pharma Co N.V.(NAMScusipN62509109)	1.9M	QoQ -8.76% (-183.6K) YoY-	All Managers (Combined)	$39.1M	QoQ -27.32% (-$14.7M) YoY-
Edgewise Therapeutics, Inc.(EWTXcusip28036F105)	1.7M	QoQ +131.01% (+962.1K) YoY-	All Managers (Combined)	$37.3M	QoQ +90.34% (+$17.7M) YoY-
ARROWHEAD PHARMACEUTICALS, INC.(ARWRcusip04280A100)	2.7M	QoQ -7.98% (-231.8K) YoY-	All Managers (Combined)	$34.0M	QoQ -37.64% (-$20.5M) YoY-
Avidity Biosciences, Inc.(RNAcusip05370A108)	1.1M	QoQ -1.48% (-16.7K) YoY-	All Managers (Combined)	$32.8M	QoQ +0.01% (-$3.5K) YoY-
Wave Life Sciences Ltd.(WVEcusipY95308105)	3.7M	QoQ -1.44% (-54.2K) YoY-	All Managers (Combined)	$29.9M	QoQ -35.62% (-$16.5M) YoY-
Taboola.com Ltd.(TBLAcusipM8744T106)	10.0M	QoQ 0.00% (-0) YoY-	All Managers (Combined)	$29.4M	QoQ -19.17% (-$7.0M) YoY-
Dyne Therapeutics, Inc.(DYNcusip26818M108)	2.7M	QoQ +101.71% (-1.4M) YoY-	All Managers (Combined)	$28.4M	QoQ -10.44% (-$3.3M) YoY-
Solid Biosciences Inc.(SLDBcusip83422E204)	7.4M	QoQ +97.80% (+3.7M) YoY-	All Managers (Combined)	$27.4M	QoQ +82.97% (+$12.4M) YoY-